Preclinical service
Central nervous systems
Behavior/Learning
| Gait analysis using CatWalk System |
| The learning ability using the Morris water maze apparatus |
Cerebral infarction
| Stenosis of the MCA (middle cerebral artery) |
| Perinatal hypoxic-ischemic encephalopathy |
Pain assessment
| Chemotherapy-induced peripheral neuropathic pain |
| Diabetic neuropathic pain(STZ-induced diabetes mellitus in rats) |
Emesis
Electroencephalogram
Parkinson’s disease model
| 6-OHDA-induced Parkinson's model in rats |
Cardiovascular systems
Myocardial ischemia
Heart failure
| Pacing-induced heart failure in dogs |
| Transverse aortic constriction (TAC) heart failure model in rats |
Hypertension
| Dahl salt-sensitive hypertensive rats |
| SHR/izm rats |
Blood pressure
Antithrombotic
| A-V shunt model in rats |
| Ferric chloride-induced thrombosis model |
Bleeding time
| Tail-cut bleeding time model |
Respiration
Pulmonary disease model
| Monocrotaline-induced pulmonary arterial hypertension in rats |
| Sugen/hypoxia model, pulmonary arterial hypertension in rats |
| Bleomycin-induced pulmonary fibrosis in mice |
Peripheral nervous systems and skeletal muscles
Peripheral arterial disease models
Fatigue models
| Treadmill exercise testing |
Nerve conduction velocity
| Sciatic nerves |
| Paclitaxel-administered animals |
Nerve-muscle preparation
| Sciatic nerve - gastrocnemius muscle |
Gastrointestinal system
Gastrointestinal mucosal damage (ulcer)
| Indomethacin-induced gastrointestinal mucosal damage in rats |
Ulcerative colitis
Hirschsprung’s disease model
| Myenteric Denervation of the Gut with Benzalkonium Chloride(mice) |
Gastrointestinal contractile activity
| Telemetry recording system for measuring of gastrointestinal contractile activity in unrestrained animal(macaques,dogs) |
| Endoscopic evaluation of gastric peristalsis(dogs) |
Antiemetic effects
Magnus mounting method
| Contraction of isolated guinea pig ileum |
Postoperative ileus model
| Surgical procedure model in rats |
Adhesion model
| Intestinal adhesion model by cecum abrasion in rats |
| Adhesion model by liver parenchymal transection in rats |
| Uterine adhesion model by uterine abrasion in rats |
Urology
Renal disease
| 5/6 nephrectomized animals (rats, dogs, mini-pigs) |
| Bilaterally nephrectomized rats |
| Cisplatin (CDDP)-induced acute kidney injury (AKI) |
| Adenine-induced chronic kidney injury in rats |
| Adenine-induced chronic kidney injury in rats |
Urethra and urinary bladder contraction
| Isolated urinary bladder mounted in Magnus organ bath |
Inflammation/Allergy
Acute inflammation models
| Carrageenan induced paw edema (rats, rabbits) |
| Cotton pellet-induced granulomas (rats) |
| Sodium urate crystal induced peritonitis (mice) |
| LPS-induced cytokine production (mice) |
Allergy-induced inflammation
| Atopic dermatitis induced by mite antigen (mice) |
Arthritis/Joint-contracture models
| Adjuvant-induced arthritis; AIA (rats) |
| Collagen typeII-induced arthritis; CIA (mice, rats, monkeys) |
| Sodium iodoacetate-induced experimental osteoarthritis (rats) |
| Meniscus partial injury models (rabbits, pigs) |
Lifestyle-related diseases
Lifestyle-related diseases