Coronary artery ligation in rats
Myocardial infarction results from coronary artery occlusion caused by thrombus formation or atherosclerotic plaque.
Surgical permanent or temporary coronary artery ligation in rats can recreate human myocardial infarction. After recreating the disease models, left ventricular dilation, reduction of cardiac function, and myocardial fibrosis are observed.
In case of evaluation of remodeling, four-week study period is the standard. We can measure cardiac function, or evaluate fibrosis area ratio in dissected heart, etc.
Masson's trichrome stained heart 28 days after model preparation.
Ejection fraction 28 days after repeated administration of candesartan cilexetil starting the day after model induction.
Echocardiogram at 28 days after model preparation (left: normal, right: myocardial infarction model).